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Invitrogen
Peptide Histidine-Methionine Monoclonal Antibody (03)
Product Details
ABS 020-03-02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
03
Immunogen
Synthetic human peptide histidine-methionine.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_667505
Product Specific Information
ABS 020-03-02 detects PHM in human samples.^M
^M
ABS 020-03-02 has been successfully used in ELISA procedures. PHM cross-reacts with PACAP (approximately 12%; incomplete, non-parallel inhibition).^M
^M
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Target Information
Human peptide histidine-methionine (PHM) is a 27-amino-acid peptide belonging to the glucagon-secretin family of peptide hormones. PHM is produced from the same prohormone as VIP, with which it shows considerable sequence homology. The VIP/PHM prohormone is produced by neurons in the central and peripheral nervous systems, often together with acetylcholine. In some situations the effect of the peptides is to reinforce and prolong the effects of neurotransmitter release. Like VIP, PHM is a vasodilator and stimulator of intestinal fluid secretion. High plasma levels of PHM are diagnostic of the corresponding peptide-producing tumor (VIPoma), associated with the watery diarrhea-hypokalemia-achlorhydria syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC13587; prepro-VIP; VIP peptides
Gene Aliases: PHM27; VIP
UniProt ID: (Human) P01282
Entrez Gene ID: (Human) 7432
positive regulation of endothelial cell proliferation
G-protein coupled receptor signaling pathway
body fluid secretion
learning or memory
positive regulation of cell proliferation
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
regulation of protein localization
negative regulation of apoptotic process
negative regulation of potassium ion transport
positive regulation of protein catabolic process
positive regulation of vasodilation
mRNA stabilization
negative regulation of smooth muscle cell proliferation
regulation of sensory perception of pain
positive regulation of penile erection
prolactin secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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